N-acetylcysteine — paediatric dose

Weight-based dosing for N-acetylcysteine in children. Category: Other.

Dose	150 mg/kg over 1 h, then 50 mg/kg/4h, then 100 mg/kg/16h
Per kg	150 mg/kg
Route	IV
Frequency	loading

Clinical notes

Paracetamol overdose. Follow local nomogram/protocol.

150 mg/kg over 1 h, then 50 mg/kg/4h, then 100 mg/kg/16h. That is 150 mg/kg per dose.

N-acetylcysteine is given by IV, loading.

Reviewed by Dr Santanu Ghosh — MBBS, MD Paediatrics (Army), IDPCCM (IAP, ICH Kolkata). Paediatrician and paediatric critical care specialist.

Compiled from standard paediatric references. Verify against a current formulary and your local protocol.

Spotted something wrong? Report an error on this page — corrections from clinicians are welcome and are reviewed before any change is published.

Last reviewed 2026-08-12.