PediRounds

Protamine — paediatric dose

Weight-based dosing for Protamine in children. Category: Anticoagulant.

Dose1 mg per 100 U of heparin in the last dose (max 50 mg); reduce for elapsed time
Maximum50 mg
Routeslow IV

Clinical notes

Hypotension / anaphylactoid reaction if given rapidly.

Sources

  • Nelson Textbook of Pediatrics, 21st edition
  • The Harriet Lane Handbook, 22nd edition
  • BNF for Children
  • PALS 2020 guidelines