OPV vaccine
Oral Polio Vaccine (bivalent) · IAP / NIS
| When to give | OPV-0 at birth (within first 15 days); OPV-1,2,3 at 6, 10, 14 wk; boosters 16–18 mo. |
|---|---|
| Dose | 2 drops orally. bOPV (Sabin): Type 1 & Type 3 each 10⁶ CCID₅₀. |
| Route | Oral |
| Site | Oral |
| Schedule / interval | Birth, 6, 10, 14 wk; booster 16–18 mo. Can be given up to 5 yr. |
Catch-up schedule
Missed doses — resume; do not restart. Can be given till 5 years.
Adverse events (AEFI)
Generally well tolerated. Extremely rare: VAPP (vaccine-associated paralytic polio) and VDPV.
Brands available in India
BioPolio (bOPV)
Special considerations
Contraindicated (VAPP/VDPV risk) in immunodeficient patients and household contacts of such patients — prefer IPV. Store in freezer / 2–8°C.
Common questions
When is the OPV vaccine given?
OPV-0 at birth (within first 15 days); OPV-1,2,3 at 6, 10, 14 wk; boosters 16–18 mo.
What is the OPV vaccine dose and route?
2 drops orally. bOPV (Sabin): Type 1 & Type 3 each 10⁶ CCID₅₀. Route: Oral. Site: Oral.
Can the OPV vaccine be given late?
Missed doses — resume; do not restart. Can be given till 5 years.
What are the side effects of the OPV vaccine?
Generally well tolerated. Extremely rare: VAPP (vaccine-associated paralytic polio) and VDPV.
Which OPV vaccine brands are available in India?
BioPolio (bOPV)
See the full IAP-ACVIP 2025 immunisation schedule →
About this page
Aligned with the IAP-ACVIP Recommended Immunization Schedule 2025 and compiled from standard paediatric references. Verify against the current product insert, the national schedule and your local protocol.
Spotted something wrong? Report an error on this page — corrections from clinicians are welcome and are reviewed before any change is published.
Last reviewed 2026-08-12.