Rotavirus vaccine
Rotavirus Vaccine · IAP / NIS
| When to give | At 6, 10, 14 wk (RV5 needs 3 doses; RV1 needs 2). |
|---|---|
| Dose | RV1 (monovalent, Rotarix-type): 1 mL orally, 2 doses. RV5 (pentavalent bovine, RotaTeq/Rotasiil): 2 mL orally, 3 doses. 116E monovalent (Rotavac): 0.5 mL (5 drops), 3 doses. |
| Route | Oral |
| Site | Oral |
| Schedule / interval | First dose 6–14 wk; ≥4 wk between doses. Complete before ~8 months. 3rd dose not required for RV1. |
Catch-up schedule
First dose must be given before 15 weeks; series completed by 8 months of age. Do not initiate late.
Adverse events (AEFI)
Mild transient diarrhoea/vomiting, irritability. Small risk of intussusception (highest after 1st dose). Efficacy 85–98% (HIC/MIC); India ~60%.
Brands available in India
Rotarix (RV1), RotaTeq / Rotasiil (RV5), Rotavac & Rotavac-5D (116E, thermostable), RotaSure
Special considerations
Rotavac-5D is a 3-dose 116E vaccine (≥10⁵ FFU/0.5 mL) stable at 2–8°C for full shelf life (no −20°C needed). Age limits are strict due to intussusception risk. Contraindicated in SCID and prior intussusception. Store 2–8°C, protect from light.
Common questions
When is the Rotavirus vaccine given?
At 6, 10, 14 wk (RV5 needs 3 doses; RV1 needs 2).
What is the Rotavirus vaccine dose and route?
RV1 (monovalent, Rotarix-type): 1 mL orally, 2 doses. RV5 (pentavalent bovine, RotaTeq/Rotasiil): 2 mL orally, 3 doses. 116E monovalent (Rotavac): 0.5 mL (5 drops), 3 doses. Route: Oral. Site: Oral.
Can the Rotavirus vaccine be given late?
First dose must be given before 15 weeks; series completed by 8 months of age. Do not initiate late.
What are the side effects of the Rotavirus vaccine?
Mild transient diarrhoea/vomiting, irritability. Small risk of intussusception (highest after 1st dose). Efficacy 85–98% (HIC/MIC); India ~60%.
Which Rotavirus vaccine brands are available in India?
Rotarix (RV1), RotaTeq / Rotasiil (RV5), Rotavac & Rotavac-5D (116E, thermostable), RotaSure
See the full IAP-ACVIP 2025 immunisation schedule →
About this page
Aligned with the IAP-ACVIP Recommended Immunization Schedule 2025 and compiled from standard paediatric references. Verify against the current product insert, the national schedule and your local protocol.
Spotted something wrong? Report an error on this page — corrections from clinicians are welcome and are reviewed before any change is published.
Last reviewed 2026-08-12.